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Extra resources for Amsacrine-Associated Cardiotoxicity
Sample text
Categorisation of the severity of an angina pectoris symptom complex normally takes place in accordance with the classification of the Canadian Cardiovascular Society (CCS) [1], which was developed on the basis of the NYHA classification of stages of heart failure. , climbing one flight of stairs at normal speed leads to angina pectoris. CCS IV characterises an inability to perform any type of bodily activity without discomfort. Patients with refractory angina pectoris (CCS III–IV) are highly symptomatic under everyday conditions, which results in massive restriction of physical functional activity.
15. 16. 17. 18. 19. 20. 21. 22. 23. 24. 25. 26. 27. 28. 29. F. Bovenzi et al. treated w ith the glycoprotein IIb/IIIa inhibitor tirofiban. N Engl J Med 344:1879–1887 Mak KH, Topol EJ (2000) Emerging concepts in the management of acute myocardial infarction in patients with diabetes mellitus. J Am Coll Cardiol 35:563–568 Fibrinolytic Therapy Trialists’ (FTT) Collaborative Group (1994) Indications for fibrinolytic therapy in suspected acute myocardial infarction: collaborative overview of early mortality and major morbidity results from all randomised trials of more than 1,000 patients.
Distal embolisation of atherothrombotic debris into the 26 C. Cavallini coronary microcirculation may also occur as a complication of the unstable plaque. For these reasons, early randomised trials such as the TIMI IIIB [14, 15] and VANQWISH trials [16] failed to demonstrate that routine use of an early invasive strategy improves the outcome compared to a conservative strategy. Furthermore, the VANQWISH trial showed a significant difference in favour of conservative treatment in the composite end-point of death and MI at 1-month and 1-year follow-up.